Insights into absence of lymphoma despite fulminant Epstein-Barr virus infection in patients with XIAP deficiency

X-linked Lymphoproliferative Syndromes (XLP), arising from mutations in SH2D1A or XIAP genes, are characterized by fulminant Epstein-Barr virus (EBV) infection. Lymphomas occur frequently in XLP-1 and in other congenital conditions with heightened EBV susceptibility, but not in XLP-2. Why XLP-2 pati...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Yizhe Sun, Janet Chou, Kevin D. Dong, Steven P. Gygi, Benjamin E. Gewurz
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2025-08-01
Subjects:	Infectious disease Virology
Online Access:	https://doi.org/10.1172/jci.insight.193787