Synthesis of <i>N</i>′-(4-/3-/2-/Non-substituted benzylidene)-4-[(4-methylphenyl)sulfonyloxy] Benzohydrazides and Evaluation of Their Inhibitory Activities against Monoamine Oxidases and β-Secretase

Nineteen tosylated acyl hydrazone derivatives were synthesized, and their inhibitory activities against monoamine oxidases (MAOs), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase (BACE-1) were evaluated. Compound <b>3o</b> was the most potent inhibitor of MAO-A...

Full description

Bibliographic Details

Published in:	Applied Sciences
Main Authors:	Hasan Erdinç Sellitepe, Jong Min Oh, İnci Selin Doğan, Sercan Yildirim, Ahmet Buğra Aksel, Geum Seok Jeong, Ahmed Khames, Mohamed A. Abdelgawad, Nicola Gambacorta, Orazio Nicolotti, Bijo Mathew, Hoon Kim
Format:	Article
Language:	English
Published:	MDPI AG 2021-06-01
Subjects:	tosylated acyl hydrazide derivatives monoamine oxidases cholinesterases β-secretase structure–activity relationship inhibitory activity
Online Access:	https://www.mdpi.com/2076-3417/11/13/5830