Sequential nanoparticle therapy targeting neutrophil hyperactivation to prevent neutrophil-induced pulmonary fibrosis

Abstract Background Pulmonary fibrosis, a major complication of severe COVID-19 and post-acute sequelae of SARS-CoV-2 infection (PASC), is driven by excessive neutrophil activation and the formation of neutrophil extracellular trap (NET). Results This study presents a sequential nanoparticle-based t...

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Bibliographic Details

Published in:	Journal of Nanobiotechnology
Main Authors:	Hye-Jin Lee, Na Kyeong Lee, Jisun Kim, Jungbum Kim, Donghyuk Seo, Ha Eun Shin, Jongsu Kim, June Hong Ahn, Se-Na Kim, Hong Sook Kim, Juwon Park, Wooram Park, Kyung Soo Hong, Chun Gwon Park, Wonhwa Lee
Format:	Article
Language:	English
Published:	BMC 2025-05-01
Subjects:	Pulmonary fibrosis Neutrophil extracellular traps Aerosolized drug delivery Chronic inflammation Post-acute sequelae of SARS-CoV-2 (PASC)
Online Access:	https://doi.org/10.1186/s12951-025-03421-y