An NMDAR positive and negative allosteric modulator series share a binding site and are interconverted by methyl groups

N-methyl-d-aspartate receptors (NMDARs) are an important receptor in the brain and have been implicated in multiple neurological disorders. Many non-selective NMDAR-targeting drugs are poorly tolerated, leading to efforts to target NMDAR subtypes to improve the therapeutic index. We describe here a...

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Bibliographic Details

Published in:	eLife
Main Authors:	Riley Perszyk, Brooke M Katzman, Hirofumi Kusumoto, Steven A Kell, Matthew P Epplin, Yesim A Tahirovic, Rhonda L Moore, David Menaldino, Pieter Burger, Dennis C Liotta, Stephen F Traynelis
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2018-05-01
Subjects:	NMDAR Allosteric modulator Pharmacology
Online Access:	https://elifesciences.org/articles/34711