Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons

Age-related cognitive decline is linked to impaired autophagy and hippocampal dysfunction. This study investigates the role of Sirtuin 2 (SIRT2) in age-related cognitive decline, focusing on its impact on autophagy and hippocampal function. Quantitative proteomic analysis revealed 67 significantly d...

Full description

Bibliographic Details

Published in:	Brain Research Bulletin
Main Authors:	Zhenyuan Zhang, Lan Zhang, Yidan Zhang, Yuan Zhao, Ya Gao, Cong Zhang, Dongxiao Li, Xiangjian Zhang, Guofeng Yang, Jian Zhang
Format:	Article
Language:	English
Published:	Elsevier 2025-10-01
Subjects:	Brain aging Autophagy Sirtuin 2 (SIRT2) Proteomic
Online Access:	http://www.sciencedirect.com/science/article/pii/S0361923025003132