Fine Tuning of an Oxidative Stress Model with Sodium Iodate Revealed Protective Effect of NF-κB Inhibition and Sex-Specific Difference in Susceptibility of the Retinal Pigment Epithelium

Oxidative stress of the retinal pigment epithelium (RPE) is a major risk factor for age-related macular degeneration (AMD). As a dry AMD model via oxidative stress, sodium iodate (NaIO₃), which is primarily toxic to the RPE, has often been used at a high dose to cause RPE deat...

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Bibliographic Details

Published in:	Antioxidants
Main Authors:	Xue Yang, Usha Rai, Jin-Yong Chung, Noriko Esumi
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Subjects:	retinal pigment epithelium sodium iodate oxidative stress IKKbeta NF-kappaB sex differences
Online Access:	https://www.mdpi.com/2076-3921/11/1/103