Synthesis of Substituted 1,2,4-Triazole-3-Thione Nucleosides Using <i>E. coli</i> Purine Nucleoside Phosphorylase

1,2,4-Triazole derivatives have a wide range of biological activities. The most well-known drug that contains 1,2,4-triazole as part of its structure is the nucleoside analogue ribavirin, an antiviral drug. Finding new nucleosides based on 1,2,4-triazole is a topical task. The aim of this study was...

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Bibliographic Details

Published in:	Biomolecules
Main Authors:	Ilya V. Fateev, Sobirdjan A. Sasmakov, Jaloliddin M. Abdurakhmanov, Abdukhakim A. Ziyaev, Shukhrat Sh. Khasanov, Farkhod B. Eshboev, Oybek N. Ashirov, Valeriya D. Frolova, Barbara Z. Eletskaya, Olga S. Smirnova, Maria Ya. Berzina, Alexandra O. Arnautova, Yulia A. Abramchik, Maria A. Kostromina, Alexey L. Kayushin, Konstantin V. Antonov, Alexander S. Paramonov, Valeria L. Andronova, Georgiy A. Galegov, Roman S. Esipov, Shakhnoz S. Azimova, Anatoly I. Miroshnikov, Irina D. Konstantinova
Format:	Article
Language:	English
Published:	MDPI AG 2024-06-01
Subjects:	nucleoside phosphorylases nucleosides ribavirin antiviral activity
Online Access:	https://www.mdpi.com/2218-273X/14/7/745