Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity

New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target. We herein report the synthesis and biological activity of a series of 1<i>H</i>-pyr...

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Bibliographic Details
Published in:Pharmaceuticals
Main Authors: Calvin Dunker, Lukas Imberg, Alena I. Siutkina, Catharina Erbacher, Constantin G. Daniliuc, Uwe Karst, Dmitrii V. Kalinin
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Subjects:
covalent inhibitor
thrombin
thrombosis
anticoagulants
pyrazole
Ullmann reaction
Online Access:https://www.mdpi.com/1424-8247/15/11/1340

Internet

https://www.mdpi.com/1424-8247/15/11/1340

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