Embryonic Stem Cell Culture Conditions Support Distinct States Associated with Different Developmental Stages and Potency

Embryonic stem cells (ESCs) are cell lines derived from the mammalian pre-implantation embryo. Here we assess the impact of derivation and culture conditions on both functional potency and ESC transcriptional identity. Individual ESCs cultured in either two small-molecule inhibitors (2i) or with kno...

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Bibliographic Details

Published in:	Stem Cell Reports
Main Authors:	Javier Martin Gonzalez, Sophie M. Morgani, Robert A. Bone, Kasper Bonderup, Sahar Abelchian, Cord Brakebusch, Joshua M. Brickman
Format:	Article
Language:	English
Published:	Elsevier 2016-08-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671116301333