Distinct subcellular localization of tau and alpha-synuclein in lewy body disease

Abstract Lewy bodies and neurofibrillary tangles, composed of α-synuclein (α-syn) and tau, respectively, often are found together in the same brain and correlate with worsening cognition. Human postmortem studies show colocalization of α-syn and tau occurs in Lewy bodies, but with limited effort to...

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Bibliographic Details

Published in:	Acta Neuropathologica Communications
Main Authors:	D. Luke Fischer, Marissa Menard, Omar Z. Abdelaziz, Nicholas M. Kanaan, Virginia G. Cobbs, Richard E. Kennedy, Geidy E. Serrano, Thomas G. Beach, Laura A. Volpicelli-Daley
Format:	Article
Language:	English
Published:	BMC 2025-01-01
Subjects:	Tau Alpha-synuclein Lewy body Neurofibrillary tangle Copathology
Online Access:	https://doi.org/10.1186/s40478-024-01913-w