Jagged1 Is Altered in Alzheimer's Disease and Regulates Spatial Memory Processing

Notch signaling plays an instrumental role in hippocampus-dependent memory formation and recent evidence indicates a displacement of Notch1 and a reduction its activity in hippocampal and cortical neurons from Alzheimer's disease (AD) patients. As Notch activation depends on ligand availability...

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Bibliographic Details

Published in:	Frontiers in Cellular Neuroscience
Main Authors:	Swananda Marathe, Muriel Jaquet, Jean-Marie Annoni, Lavinia Alberi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2017-08-01
Subjects:	Notch signaling Jagged1 hippocampus Alzheimer's disease memory
Online Access:	http://journal.frontiersin.org/article/10.3389/fncel.2017.00220/full