Characterization of Active MMP9 in Chronic Inflammatory Diseases Using a Novel Anti-MMP9 Antibody

Matrix metalloproteinase 9 (MMP9), a protease implicated in multiple diseases, is secreted as an inactive zymogen and requires proteolytic removal of the pro-domain for activation. The relative levels and functionality of the pro- and active-MMP9 isoforms in tissues are not characterized. We generat...

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Bibliographic Details
Published in:Antibodies
Main Authors: Maile Velasquez, Chris O’Sullivan, Robert Brockett, Amanda Mikels-Vigdal, Igor Mikaelian, Victoria Smith, Andrew E. Greenstein
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Subjects:
active MMP9
MMP9 function
andecaliximab
Online Access:https://www.mdpi.com/2073-4468/12/1/9

Internet

https://www.mdpi.com/2073-4468/12/1/9

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