Multi-omics approach to reveal follicular metabolic changes and their effects on oocyte competence in PCOS patients

BackgroundPolycystic ovary syndrome (PCOS) is a common heterogeneous disorder linked with endocrine and metabolic disturbances. The underlying mechanism of PCOS, especially its effect on oocyte competence, remains unclear. The study aimed to identify abnormal follicular metabolic changes using a mul...

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Bibliographic Details

Published in:	Frontiers in Endocrinology
Main Authors:	Yuezhou Chen, Minyu Xie, Siyun Wu, Zehua Deng, Yan Tang, Yiqing Guan, Yun Ye, Qiandong He, Lei Li
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-10-01
Subjects:	polycystic ovary syndrome follicle fluid cumulus cells transcriptomics metabolomics oocyte competence
Online Access:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1426517/full