Defective Excitatory/Inhibitory Synaptic Balance and Increased Neuron Apoptosis in a Zebrafish Model of Dravet Syndrome

Dravet syndrome is a type of severe childhood epilepsy that responds poorly to current anti-epileptic drugs. In recent years, zebrafish disease models with Scn1Lab sodium channel deficiency have been generated to seek novel anti-epileptic drug candidates, some of which are currently undergoing clini...

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Bibliographic Details

Published in:	Cells
Main Authors:	Alexandre Brenet, Rahma Hassan-Abdi, Julie Somkhit, Constantin Yanicostas, Nadia Soussi-Yanicostas
Format:	Article
Language:	English
Published:	MDPI AG 2019-10-01
Subjects:	dravet syndrome calcium imaging local field potential excitatory/inhibitory balance apoptosis in vivo imaging zebrafish <i>scn1lab</i> morpholino scn1lab<sup>aug</sup>
Online Access:	https://www.mdpi.com/2073-4409/8/10/1199