Assessing inflammatory protein biomarkers in COPD subjects with and without alpha-1 antitrypsin deficiency

Abstract Rationale Individuals homozygous for the Alpha-1 Antitrypsin (AAT) Z allele (Pi*ZZ) exhibit heterogeneity in COPD risk. COPD occurrence in non-smokers with AAT deficiency (AATD) suggests that inflammatory processes may contribute to COPD risk independently of smoking. We hypothesized that i...

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Bibliographic Details

Published in:	Respiratory Research
Main Authors:	Matthew Moll, Brian D. Hobbs, Katherine A. Pratte, Chengyue Zhang, Auyon J. Ghosh, Russell P. Bowler, David A. Lomas, Edwin K. Silverman, Dawn L. DeMeo
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Online Access:	https://doi.org/10.1186/s12931-025-03320-8