Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

Recently, genetic association findings for nicotine dependence, smoking behavior, and smoking-related diseases converged to implicate the chromosome 15q25.1 region, which includes the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit genes. In particular, association with the nonsynonymous...

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Published in:	PLoS Genetics
Main Authors:	Nancy L Saccone, Robert C Culverhouse, Tae-Hwi Schwantes-An, Dale S Cannon, Xiangning Chen, Sven Cichon, Ina Giegling, Shizhong Han, Younghun Han, Kaisu Keskitalo-Vuokko, Xiangyang Kong, Maria Teresa Landi, Jennie Z Ma, Susan E Short, Sarah H Stephens, Victoria L Stevens, Lingwei Sun, Yufei Wang, Angela S Wenzlaff, Steven H Aggen, Naomi Breslau, Peter Broderick, Nilanjan Chatterjee, Jingchun Chen, Andrew C Heath, Markku Heliövaara, Nicole R Hoft, David J Hunter, Majken K Jensen, Nicholas G Martin, Grant W Montgomery, Tianhua Niu, Thomas J Payne, Leena Peltonen, Michele L Pergadia, John P Rice, Richard Sherva, Margaret R Spitz, Juzhong Sun, Jen C Wang, Robert B Weiss, William Wheeler, Stephanie H Witt, Bao-Zhu Yang, Neil E Caporaso, Marissa A Ehringer, Tim Eisen, Susan M Gapstur, Joel Gelernter, Richard Houlston, Jaakko Kaprio, Kenneth S Kendler, Peter Kraft, Mark F Leppert, Ming D Li, Pamela A F Madden, Markus M Nöthen, Sreekumar Pillai, Marcella Rietschel, Dan Rujescu, Ann Schwartz, Christopher I Amos, Laura J Bierut
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-08-01
Online Access:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1001053&type=printable