Identification of molecular signatures defines the differential proteostasis response in induced spinal and cranial motor neurons

Summary: Amyotrophic lateral sclerosis damages proteostasis, affecting spinal and upper motor neurons earlier than a subset of cranial motor neurons. To aid disease understanding, we exposed induced cranial and spinal motor neurons (iCrMNs and iSpMNs) to proteotoxic stress, under which iCrMNs showed...

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Bibliographic Details

Published in:	Cell Reports
Main Authors:	Ana Paula Zen Petisco Fiore, Shuvadeep Maity, Lauren Jeffery, Disi An, Justin Rendleman, Dylan Iannitelli, Hyungwon Choi, Esteban Mazzoni, Christine Vogel
Format:	Article
Language:	English
Published:	Elsevier 2024-03-01
Subjects:	motor neurons amyotrophic lateral sclerosis Ublcp1 unfolded protein response proteasome
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211124724002134