Targeting intestinal inflammation using locked nucleic acids delivered via lipid nanoparticles

Abstract Locked nucleic acids are a third-generation antisense oligonucleotides with high binding affinity. A major limitation is the high dosages they require to achieve efficacy which may induce unwanted adverse effects. Here, we report the use of Lipid-based nanoparticles to deliver locked nuclei...

Full description

Bibliographic Details

Published in:	Nature Communications
Main Authors:	Shahd Qassem, Gonna Somu Naidu, Meir Goldsmith, Dor Breier, Riccardo Rampado, Srinivas Ramishetti, Michael Keller, Felix Schumacher, Kara G. Lassen, Leilah Otikovs, Roman Kamyshinsky, Inbal Hazan-Halevy, Dan Peer
Format:	Article
Language:	English
Published:	Nature Portfolio 2025-08-01
Online Access:	https://doi.org/10.1038/s41467-025-63037-6