Overcoming T-cell exhaustion in glioblastoma: A narrative review

Immunotherapy is typically ineffective against glioblastoma (GBM) due to inherent and adaptive resistance. Initial immunotherapy results for GBM have been disappointing. In this regard, T-cell exhaustion is a major barrier to successful treatment. The recognition of exhausted CD8+ T cell (Tex) pedig...

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Bibliographic Details

Published in:	Glioma
Main Authors:	Xuya Wang, Xisen Wang, Jiabo Li
Format:	Article
Language:	English
Published:	Wolters Kluwer Medknow Publications 2022-01-01
Subjects:	brain tumor glioblastoma immunotherapy t-cell exhaustion tumor microenvironment
Online Access:	http://www.jglioma.com/article.asp?issn=2589-6113;year=2022;volume=5;issue=2;spage=56;epage=61;aulast=Wang