The major TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the ageing human hippocampus

Abstract Background The risk for dementia increases exponentially from the seventh decade of life. Identifying and understanding the biochemical changes that sensitize the ageing brain to neurodegeneration will provide new opportunities for dementia prevention and treatment. This study aimed to dete...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:Molecular Neurodegeneration
المؤلفون الرئيسيون: Jun Yup Lee, Dylan J Harney, Jonathan D Teo, John B Kwok, Greg T. Sutherland, Mark Larance, Anthony S Don
التنسيق: مقال
اللغة:الإنجليزية
منشور في: BMC 2023-09-01
الموضوعات:
TMEM106B
Proteomic
Lipidomic
Sphingolipid
Neurodegeneration
Ageing
الوصول للمادة أونلاين:https://doi.org/10.1186/s13024-023-00650-3

الانترنت

https://doi.org/10.1186/s13024-023-00650-3

مواد مشابهة