Trispecific SEED antibodies engineered for neutrophil-mediated cell killing

Immunoglobulin (Ig) A has attracted interest as a proposed therapeutic agent due to its ability to engage cell groups differently compared to an IgG scaffold and elicit tumor eradication. Further, its multimeric forms enable increased flexibility in the design of available paratopes. The latter is p...

Full description

Bibliographic Details

Published in:	mAbs
Main Authors:	Veronica Natale, Gergely Heves, Katharina Stadlbauer, Florian Rüker, Vanessa Siegmund, Lukas Pekar, Stefan Zielonka, Lars Toleikis, Stefan Becker, Gordana Wozniak-Knopp
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	ADCC bispecific antibody EGFR Fc alpha RI immunoglobulin a neutrophils
Online Access:	https://www.tandfonline.com/doi/10.1080/19420862.2025.2532851