Defining Exposure Predictors of Meropenem That Are Associated with Improved Survival for Severe Bacterial Infection: A Preclinical PK/PD Study in Sepsis Rat Model

<b>Background</b>: The pharmacokinetic/pharmacodynamic (PK/PD) index of carbapenems that best correlates with in vivo antimicrobial activity is percent time of dosing interval in which free drug concentration remains above MIC (%<i>f</i>T > MIC), while the magnitudes of th...

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Bibliographic Details

Published in:	Antibiotics
Main Authors:	Yan Wang, Lanyu Liu, Qiping Wu, Qiufen Yin, Feifan Xie
Format:	Article
Language:	English
Published:	MDPI AG 2022-11-01
Subjects:	pharmacokinetics PK/PD survival meropenem sepsis rat model
Online Access:	https://www.mdpi.com/2079-6382/11/11/1660