Differential Coupling of Human Endothelin Type A Receptor to Gq/11 and G12 Proteins: the Functional Significance of Receptor Expression Level in Generating Multiple Receptor Signaling

This study examines the influence of receptor expression level on signaling pathways activated via endothelin type A receptor (ETAR) expressed in Chinese hamster ovary cells at 32,100 (ETAR-high-CHO) and 893 (ETAR-low-CHO) fmol·mg protein−1. Endothelin-1 (ET-1) elicited a sustained increase in intra...

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Bibliographic Details

Published in:	Journal of Pharmacological Sciences
Main Authors:	Takahiro Horinouchi, Hiroshi Asano, Tunaki Higa, Arata Nishimoto, Tadashi Nishiya, Ikunobu Muramatsu, Soichi Miwa
Format:	Article
Language:	English
Published:	Elsevier 2009-01-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861319310709