Exploring the Two Coupled Conformational Changes That Activate the Munc18-1/Syntaxin-1 Complex

Calcium-dependent synaptic vesicle exocytosis is mediated by SNARE complex formation. The transition from the Munc18-1/syntaxin-1 complex to the SNARE complex is catalyzed by the Munc13-1 MUN domain and involves at least two conformational changes: opening of the syntaxin-1 linker region and extensi...

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Bibliographic Details

Published in:	Frontiers in Molecular Neuroscience
Main Authors:	Jihong Gong, Xianping Wang, Chaoyang Cui, Yuyang Qin, Ziqi Jin, Cong Ma, Xiaofei Yang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-12-01
Subjects:	Munc18-1 Munc13-1 syntaxin-1 synapse exocytosis SNARE complex
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2021.785696/full