A randomized phase 3 trial of total neoadjuvant therapy (induction chemotherapy, neoadjuvant chemoradiation, neoadjuvant chemotherapy, and surgery) vs. standard long-term chemoradiation therapy (neoadjuvant chemoradiation, surgery, and adjuvant chemotherapy) in locally advanced rectal cancer

PurposeThe management of rectal adenocarcinoma has evolved during the last decade, shifting from a conventional neoadjuvant chemoradiotherapy, surgery, and adjuvant chemotherapy in all cases to a total neoadjuvant approach, especially in locally advanced tumors when a sphincter-sparing surgery has b...

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Bibliographic Details

Published in:	Frontiers in Oncology
Main Authors:	Freshte Foroughi, Seyed Alireza Javadinia, Roham Salek
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Subjects:	rectal cancer total neoadjuvant therapy neoadjuvant chemotherapy adjuvant chemotherapy neoadjuvant chemoradiotherapy randomized controlled trial
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2024.1468279/full