Reduced calcineurin protein levels and activity in exon-1 mouse models of Huntington's disease: Role in excitotoxicity

Calcineurin is a serine/threonine phosphatase involved in the regulation of glutamate receptors signaling. Here, we analyzed whether the regulation of calcineurin protein levels and activity modulates the susceptibility of striatal neurons to excitotoxicity in R6/1 and R6/1:BDNF+/− mouse models of H...

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Bibliographic Details

Published in:	Neurobiology of Disease
Main Authors:	Xavier Xifró, Albert Giralt, Ana Saavedra, Juan M. García-Martínez, Miguel Díaz-Hernández, José J. Lucas, Jordi Alberch, Esther Pérez-Navarro
Format:	Article
Language:	English
Published:	Elsevier 2009-12-01
Subjects:	Calcineurin A Calcineurin B Conditional mouse model Huntingtin Quinolinic acid R6/1
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996109002393