Ultrasound-actuated ion homeostasis perturbator for oxidative damage-augmented Ca2+ interference therapy and combined immunotherapy

Calcium ion therapy has shown promise for cancer treatment, but its efficacy is limited by the cellular calcium buffering mechanism. Herein, an ion homeostasis disruptor (PCCa) was synthesized using an in situ mineralization method. The surface of the porphyrin-metal-organic framework PCN was coated...

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Bibliographic Details

Published in:	Materials Today Bio
Main Authors:	Mi Yang, Yaqin Hu, Xiuxiu Hao, Qiaoqi Chen, Yang Cao, Haitao Ran, Wei Zhang
Format:	Article
Language:	English
Published:	Elsevier 2025-06-01
Subjects:	Ultrasound Sonodynamic therapy Reactive oxygen species Immunogenic death
Online Access:	http://www.sciencedirect.com/science/article/pii/S2590006425002248