Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program

Abstract Background Epigenetic programming during development is essential for determining cell lineages, and alterations in this programming contribute to the initiation of embryonal tumour development. In neuroblastoma, neural crest progenitors block their course of natural differentiation into sy...

Full description

Bibliographic Details

Published in:	Molecular Cancer
Main Authors:	Carlos Jiménez, Roberta Antonelli, Mariona Nadal-Ribelles, Laura Devis-Jauregui, Pablo Latorre, Carme Solé, Marc Masanas, Adrià Molero-Valenzuela, Aroa Soriano, Josep Sánchez de Toledo, David Llobet-Navas, Josep Roma, Francesc Posas, Eulàlia de Nadal, Soledad Gallego, Lucas Moreno, Miguel F. Segura
Format:	Article
Language:	English
Published:	BMC 2022-09-01
Subjects:	Epigenetics Epigenomics Cancer Neuroblastoma Chromatin remodelling SWI/SNF
Online Access:	https://doi.org/10.1186/s12943-022-01643-4