Anti-Bovine Programmed Death-1 Rat–Bovine Chimeric Antibody for Immunotherapy of Bovine Leukemia Virus Infection in Cattle

Blockade of immunoinhibitory molecules, such as programmed death-1 (PD-1)/PD-ligand 1 (PD-L1), is a promising strategy for reinvigorating exhausted T cells and preventing disease progression in a variety of chronic infections. Application of this therapeutic strategy to cattle requires bovinized chi...

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出版年:	Frontiers in Immunology
主要な著者:	Tomohiro Okagawa, Satoru Konnai, Asami Nishimori, Naoya Maekawa, Ryoyo Ikebuchi, Shinya Goto, Chie Nakajima, Junko Kohara, Satoshi Ogasawara, Yukinari Kato, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
フォーマット:	論文
言語:	英語
出版事項:	Frontiers Media S.A. 2017-06-01
主題:	immunoinhibitory molecules programmed death-1 PD-ligand 1 T-cell exhaustion immunotherapy chimeric antibody
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fimmu.2017.00650/full