Reporting and communication of sample size calculations in adaptive clinical trials: a review of trial protocols and grant applications

Abstract Background An adaptive design allows modifying the design based on accumulated data while maintaining trial validity and integrity. The final sample size may be unknown when designing an adaptive trial. It is therefore important to consider what sample size is used in the planning of the st...

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Bibliographic Details

Published in:	BMC Medical Research Methodology
Main Authors:	Qiang Zhang, Munyaradzi Dimairo, Steven A. Julious, Jen Lewis, Zihang Yu
Format:	Article
Language:	English
Published:	BMC 2024-09-01
Subjects:	Adaptive design Randomised controlled trial Sample size estimation Transparency Reporting
Online Access:	https://doi.org/10.1186/s12874-024-02339-7