Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway

Abstract Alcohol-related liver disease (ALD), a condition caused by alcohol overconsumption, occurs in three stages of liver injury including steatosis, hepatitis, and cirrhosis. DEP domain-containing protein 5 (DEPDC5), a component of GAP activities towards Rags 1 (GATOR1) complex, is a repressor o...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Lin Xu, Xinge Zhang, Yue Xin, Jie Ma, Chenyan Yang, Xi Zhang, Guoqing Hou, Xiaocheng Charlie Dong, Zhaoli Sun, Xiwen Xiong, Xuan Cao
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-07-01
Online Access:	https://doi.org/10.1038/s41419-021-03980-6