Transthyretin V122I variant and protein affect cardiac severity and mortality in sickle cell disease

Abstract: The amyloidogenic V122I variant of the transthyretin (TTR) gene is found in ∼3% of African American individuals and increases cardiovascular mortality risk after the age of 65 years. Sickle cell disease (SCD) primarily affects individuals of African descent, leading to multiorgan damage an...

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Bibliographic Details

Published in:	Blood Advances
Main Authors:	Haiou Li, Shijinqiu Gao, Xunde Wang, Nancy Asomaning, Anna Conrey, Britney Kruah, Jungnam Joo, Colin O. Wu, Vandana Sachdev, Swee Lay Thein
Format:	Article
Language:	English
Published:	Elsevier 2026-06-01
Online Access:	http://www.sciencedirect.com/science/article/pii/S2473952926002600