Application of cysteinyl prolyl ester for the synthesis of cyclic peptides containing an RGD sequence and their biological activity measurement

Cysteinyl RGD-peptidyl cysteinyl prolyl esters, which have different configurations at the cysteine and proline residues, were synthesized by the solid-phase method and cyclized by the native chemical ligation reaction. Cyclization efficiently proceeded to give cyclic peptides, regardless of the dif...

Full description

Bibliographic Details

Published in:	Frontiers in Chemistry
Main Authors:	Akina Yamada, Toshiki Takei, Toru Kawakami, Yukimasa Taniguchi, Kiyotoshi Sekiguchi, Hironobu Hojo
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-05-01
Subjects:	cyclic peptide cysteinyl prolyl ester native chemical ligation RGD inhibitor
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2024.1391678/full