Doxorubicin-conjugated siRNA lipid nanoparticles for combination cancer therapy

Evasion of apoptosis is a hallmark of cancer, attributed in part to overexpression of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2). In a variety of cancer types, including lymphoma, Bcl-2 is overexpressed. Therapeutic targeting of Bcl-2 has demonstrated efficacy in the clinic and is the subj...

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Bibliographic Details

Published in:	Acta Pharmaceutica Sinica B
Main Authors:	Kamila Butowska, Xuexiang Han, Ningqiang Gong, Rakan El-Mayta, Rebecca M. Haley, Lulu Xue, Wenqun Zhong, Wei Guo, Karin Wang, Michael J. Mitchell
Format:	Article
Language:	English
Published:	Elsevier 2023-04-01
Subjects:	Lipid nanoparticles Doxorubicin Bcl-2 siRNA delivery Chemotherapy Lymphoma
Online Access:	http://www.sciencedirect.com/science/article/pii/S2211383522003239