Engineering safe anti-CD19-CD28ζ CAR T cells with CD8a hinge domain in serum-free media for adoptive immunotherapy

BackgroundDespite the curative potential, high cost of manufacturing and the toxicities limits the wider access of Chimeric Antigen Receptor (CAR) T cell therapy in global medicine. CARs are modular synthetic antigen receptors integrating the single-chain variable fragment (scFv) of an immunoglobuli...

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الحاوية / القاعدة:	Frontiers in Immunology
المؤلفون الرئيسيون:	Muthuganesh Muthuvel, Thamizhselvi Ganapathy, Trent Spencer, Sunil S. Raikar, Saravanabhavan Thangavel, Alok Srivastava, Sunil Martin
التنسيق:	مقال
اللغة:	الإنجليزية
منشور في:	Frontiers Media S.A. 2025-05-01
الموضوعات:	CD19 CAR T cells B lineage malignancies serum free media SIN vector NALM-6
الوصول للمادة أونلاين:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1545549/full