The mechanotransduction-immune axis in organ fibrosis: dual regulatory mechanisms and translational therapeutic perspectives

Organ fibrosis represents a final common pathway of chronic tissue injury, characterized by persistent extracellular matrix (ECM) accumulation and progressive loss of organ function. While canonical inflammatory and profibrotic cascades have been extensively studied, emerging evidence highlights the...

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Bibliographic Details

Published in:	Frontiers in Immunology
Main Authors:	Chao Lei, Dongjie Wu, Houyan Zhang, Zhiya Yang, Bohao Huang, Jie Wang, Yanbo Li, Wenliang Lv
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-10-01
Subjects:	organ fibrosis mechanotransduction immune extracellular matrix therapeutic target
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1670213/full