Irisin inhibits microglial senescence via TFAM-mediated mitochondrial metabolism in a mouse model of tauopathy
Abstract Background The accumulation of senescent microglia has been highlighted as a critical contributor to the progression of tauopathies. Irisin, a muscle-derived hormone produced by the proteolytic cleavage of Fibronectin-domain III containing 5 (FNDC5), mediates the pleiotropic effects of exer...
| الحاوية / القاعدة: | Immunity & Ageing |
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| المؤلفون الرئيسيون: | , , , , , , , , |
| التنسيق: | مقال |
| اللغة: | الإنجليزية |
| منشور في: |
BMC
2024-05-01
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| الموضوعات: | |
| الوصول للمادة أونلاين: | https://doi.org/10.1186/s12979-024-00437-0 |