Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis

Abstract Atherosclerosis is an inflammatory disorder responsible for cardiovascular disease. Reactivation of efferocytosis, the phagocytic removal of cells by macrophages, has emerged as a translational target for atherosclerosis. Systemic blockade of the key ‘don’t-eat-me’ molecule, CD47, triggers...

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Bibliographic Details

Published in:	Nature Communications
Main Authors:	Sharika Bamezai, Yapei Zhang, Manisha Kumari, Mozhgan Lotfi, Tom Alsaigh, Lingfeng Luo, Gayatri Suresh Kumar, Fudi Wang, Jianqin Ye, Madhu Puri, Romila Manchanda, Sesha Paluri, Shaunak S. Adkar, Yoko Kojima, Alice Ingelsson, Caitlin F. Bell, Nicolas G. Lopez, Changhao Fu, Ryan B. Choi, Zach Miller, Leo Barrios, Susan Walsh, Ferhaan Ahmad, Lars Maegdefessel, Bryan Ronain Smith, Nicholas J. Leeper
Format:	Article
Language:	English
Published:	Nature Portfolio 2024-09-01
Online Access:	https://doi.org/10.1038/s41467-024-52005-1