Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients

To explore SLE staging markers, we analyzed eccDNA in plasma using circular sequencing, comparing healthy controls (HC), active SLE (ASLE), and inactive SLE (ISLE) patients. We found higher eccDNA levels and lower GC content in ASLE and ISLE compared to healthy controls, with a negative correlation...

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Bibliographic Details

Published in:	Epigenetics
Main Authors:	Yali Peng, Huihui Tao, Dongzhou Liu, Donger Tang, Chunmei Wen, Mengyao Wu, Tiantian Xu, Guoying Wang, Xuejia Zheng, Yong Dai
Format:	Article
Language:	English
Published:	Taylor & Francis Group 2025-12-01
Subjects:	Systemic lupus erythematosus (SLE) extrachromosomal circular DNA (eccDNA) biomarkers active and inactive SLE differential expression analysis circular sequencing
Online Access:	https://www.tandfonline.com/doi/10.1080/15592294.2025.2477903