NR4A family members regulate T cell tolerance to preserve immune homeostasis and suppress autoimmunity

The NR4A family of orphan nuclear receptors (Nr4a1–3) plays redundant roles to establish and maintain Treg identity; deletion of multiple family members in the thymus results in Treg deficiency and a severe inflammatory disease. Consequently, it has been challenging to unmask redundant functions of...

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Bibliographic Details

Published in:	JCI Insight
Main Authors:	Ryosuke Hiwa, Hailyn V. Nielsen, James L. Mueller, Ravi Mandla, Julie Zikherman
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2021-09-01
Subjects:	Autoimmunity Immunology
Online Access:	https://doi.org/10.1172/jci.insight.151005