Deciphering gene regulatory programs in mouse embryonic skin through single-cell multiomics analysis

Abstract Background Cell type-specific transcriptional heterogeneity in embryonic mouse skin is well-documented, but few studies have investigated the regulatory mechanisms. Here, we present high-throughput single-cell chromatin accessibility and transcriptome sequencing (HT-scCAT-seq), a method tha...

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Bibliographic Details

Published in:	Genome Biology
Main Authors:	Qiuting Deng, Pengfei Cai, Yingjie Luo, Zhongjin Zhang, Wen Ma, Zijie Huang, Xiaoya Chen, Shijie Hao, Weiguang Ma, Jiangshan Xu, Chunqing Wang, Mengnan Cheng, Xiumei Lin, Ru Zhou, Shanshan Duan, Junjie Chen, Ronghai Li, Xuyang Shi, Chang Liu, Liang Wu, Peng Gao, Jianting Li, Xiao Yang, Xiangdong Wang, Jun Xie, Longqi Liu, Yue Yuan, Chuanyu Liu
Format:	Article
Language:	English
Published:	BMC 2025-07-01
Subjects:	HT-scCAT-seq Cis-regulatory elements Embryonic skin development
Online Access:	https://doi.org/10.1186/s13059-025-03652-0