Combination of bazedoxifene with chemotherapy and SMAC-mimetics for the treatment of colorectal cancer

Abstract Excessive STAT3 signalling via gp130, the shared receptor subunit for IL-6 and IL-11, contributes to disease progression and poor survival outcomes in patients with colorectal cancer. Here, we provide evidence that bazedoxifene inhibits tumour growth via direct interaction with the gp130 re...

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Bibliographic Details

Published in:	Cell Death and Disease
Main Authors:	Rhynelle S. Dmello, Michelle Palmieri, Pathum S. Thilakasiri, Larissa Doughty, Tracy L. Nero, Ashleigh R. Poh, Sarah Q. To, Erinna F. Lee, W. Douglas Fairlie, Lisa Mielke, Michael W. Parker, Ivan K. H. Poon, Eduard Batlle, Matthias Ernst, Ashwini L. Chand
Format:	Article
Language:	English
Published:	Nature Publishing Group 2024-04-01
Online Access:	https://doi.org/10.1038/s41419-024-06631-8