A tunable human intestinal organoid system achieves controlled balance between self-renewal and differentiation
Abstract A balance between stem cell self-renewal and differentiation is required to maintain concurrent proliferation and cellular diversification in organoids; however, this has proven difficult in homogeneous cultures devoid of in vivo spatial niche gradients for adult stem cell-derived organoids...
| Published in: | Nature Communications |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41467-024-55567-2 |