Multiplex Screening Assay for Identifying Cytotoxic CD8+ T Cell Epitopes

The cytotoxicity of epitope-specific CD8+ T cells is usually measured indirectly through IFNγ production. Existing assays that directly measure this activity are limited mainly to measurements of up to two specificities in a single reaction. Here, we develop a multiplex cytotoxicity assay that allow...

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Bibliographic Details
Published in:Frontiers in Immunology
Main Authors: Chek Meng Poh, Jian Zheng, Rudragouda Channappanavar, Zi Wei Chang, Thi H. O. Nguyen, Laurent Rénia, Katherine Kedzierska, Stanley Perlman, Leo L. M. Poon
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Subjects:
influenza
Plasmodium
MERS
CD8 T cell
cytotoxicity
multiplex assay
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00400/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.00400/full

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