The interleukin 1 receptor antagonist anakinra to reduce disease severity of palmoplantar pustulosis in adults: APRICOT RCT and PLUM mechanistic study

Background: Palmoplantar pustulosis is a rare, debilitating, chronic skin disease involving the hands and feet, and there are limited treatment options. Mechanistic findings suggest that interleukin 1 may be a pathogenic driver. Objective: To determine whether or not anakinra [Sobi (Swedish Orphan B...

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Bibliographic Details

Published in:	Efficacy and Mechanism Evaluation
Main Authors:	Suzie Cro, Victoria Cornelius, Francesca Capon, Jonathan Barker, David Burden, Christopher Griffiths, Helen Jane Lachmann, Helen McAteer, Prakash Patel, Andrew Pink, Nick Reynolds, Richard Warren, Catherine Smith
Format:	Article
Language:	English
Published:	NIHR Journals Library 2022-03-01
Subjects:	palmoplantar pustulosis anakinra interleukin il-36/il-1 axis il-1 antagonist randomised controlled trial ppp pustular psoriasis
Online Access:	https://doi.org/10.3310/MXPK2427