The genetic duet of concurrent RASAL1 and PTEN alterations promotes cancer aggressiveness by cooperatively activating the PI3K–AKT pathway

The significance of the prominent tumor suppressor gene for RAS protein activator‐like 1 (RASAL1) could be better understood by combined genetic, clinical, and functional studies. Here, we investigated the oncogenic and clinical impacts of genetic alterations of RASAL1, particularly when coexisting...

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Bibliographic Details
Published in:Molecular Oncology
Main Authors: Xiaopei Shen, Jie Tan, Rengyun Liu, Guangwu Zhu, Lisa Rooper, Mingzhao Xing
Format: Article
Language:English
Published: Wiley 2025-01-01
Subjects:
cancer aggressiveness
PI3K pathway
PTEN
RASAL1
tumor suppressor gene
Online Access:https://doi.org/10.1002/1878-0261.13701

Internet

https://doi.org/10.1002/1878-0261.13701

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