Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2

The recent COVID-19 pandemic again highlighted the urgent need for broad-spectrum antivirals, both for therapeutic use in acute viral infection and for pandemic preparedness in general. The targeting of host cell factors hijacked by viruses during their replication cycle presents one possible strate...

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Bibliographic Details

Published in:	Frontiers in Cellular and Infection Microbiology
Main Authors:	Helen Hoffmann, Marina Ebensperger, Annika Schönsiegel, Hazem Hamza, Julia Koch-Heier, André Schreiber, Stephan Ludwig, Michael Schindler, Oliver Planz
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-10-01
Subjects:	SARS-CoV-2 influenza virus EC50 IC50 Raf/MEK/ERK MEK inhibitor
Online Access:	https://www.frontiersin.org/articles/10.3389/fcimb.2023.1264983/full