Identification of truncated variants in GLI family zinc finger 3 (GLI3) associated with polydactyly

Abstract Background Polydactyly is a prevalent congenital anomaly with an incidence of 2.14 per 1000 live births in China. GLI family zinc finger 3 (GLI3) is a classical causative gene of polydactyly, and serves as a pivotal transcription factor in the hedgehog signaling pathway, regulating the deve...

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Bibliographic Details

Published in:	Journal of Orthopaedic Surgery and Research
Main Authors:	Run-Yan Wang, Qin Xiong, Si-Hua Chang, Jie-Yuan Jin, Rong Xiang, Lei Zeng, Fang Yu
Format:	Article
Language:	English
Published:	BMC 2024-07-01
Subjects:	Polydactyly GLI3 Truncated variant Isolated polydactyly Greig cephalopolysyndactyly syndrome
Online Access:	https://doi.org/10.1186/s13018-024-04928-0