Overlapping group screening for detection of gene-environment interactions with application to TCGA high-dimensional survival genomic data

Abstract Background In the context of biomedical and epidemiological research, gene-environment (G-E) interaction is of great significance to the etiology and progression of many complex diseases. In high-dimensional genetic data, two general models, marginal and joint models, are proposed to identi...

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Bibliographic Details

Published in:	BMC Bioinformatics
Main Authors:	Jie-Huei Wang, Kang-Hsin Wang, Yi-Hau Chen
Format:	Article
Language:	English
Published:	BMC 2022-05-01
Subjects:	Gene-environment interaction Joint model Lasso Overlapping group screening Survival prediction TCGA
Online Access:	https://doi.org/10.1186/s12859-022-04750-7