Structure-Based Optimization of 1,2,4-Triazole-3-Thione Derivatives: Improving Inhibition of NDM-/VIM-Type Metallo-β-Lactamases and Synergistic Activity on Resistant Bacteria

The worldwide emergence and dissemination of Gram-negative bacteria expressing metallo-β-lactamases (MBLs) menace the efficacy of all β-lactam antibiotics, including carbapenems, a last-line treatment usually restricted to severe pneumonia and urinary tract infections. Nonetheless, no MBL inhibitor...

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Bibliographic Details

Published in:	Pharmaceuticals
Main Authors:	Matteo Bersani, Mariacristina Failla, Filippo Vascon, Eleonora Gianquinto, Laura Bertarini, Massimo Baroni, Gabriele Cruciani, Federica Verdirosa, Filomena Sannio, Jean-Denis Docquier, Laura Cendron, Francesca Spyrakis, Loretta Lazzarato, Donatella Tondi
Format:	Article
Language:	English
Published:	MDPI AG 2023-12-01
Subjects:	1,2,4-triazole-3-thione structure-based drug design NDM-1 competitive inhibitors resistance
Online Access:	https://www.mdpi.com/1424-8247/16/12/1682